Rheumatoid nodules are commonly talked about when rheumatoid arthritis (RA) is discussed. It might surprise you to know that only 7% of those newly diagnosed with RA have rheumatoid nodules. So they are not characteristic symptoms of newly diagnosed RA. Overtime, about 25% of those with positive Rheumatoid Factor (RF) develop nodules. Nodules are frequently present in the more severe cases of RA, those more likely to have rapid progression of joint destruction and to develop vasculitis.  75% of those with Felty’s syndrome, more common in white males, have rheumatoid nodules. Current smokers with RA plus nodules usually have more severe disease. In those with seronegative rheumatoid arthritis, about 6% develop rheumatoid nodules. The condition of having rheumatoid nodules is called rheumatoid nodulosis. The nodules form below the skin near joints. They are firm and frequently moveable. They are not tender and are not usually harmful. They are 2 mm (.008 inch) to 5 cm (2 inch) and may occur singly or in clusters. They are formed in three, under the microscope, stages: acute inflammation …