All posts filed under: Drugs

The core treatment for RA is an arsenal of drugs

Actemra as a possibility for My RA

My journey through the biologic DMARDs  began with infusions of Rituxan. I had no relief from my RA with Rituxan. Next in line were infusions of Orencia. Orencia gave me about 20% relief. At the time it was better than nothing. Orencia worked for over nine months and then stopped working. At the time I had a worse than normal flare and developed a horrible flu. Up to that point I hadn’t had a cold or a sinus infection for 3 years. After about six weeks I was started on infusions of Remicade. Remicade has three loading doses scheduled 2 weeks apart. I completed the loading doses and then became terribly ill. I felt like I was in ‘a failure to thrive’ situation. Absolutely no energy, listless is a good word. I moved into a bad flare which overshadowed the side effects of the Remicade. I was in a bad way for over a month. Remicade is a TNF inhibitor (TNFi). The recommended suggestion is that if a TNFi is stopped because it doesn’t work, another TNFi …

Methotrexate NSAID or DMARD ?

I can now count myself  as one of the few who has read the package insert for methotrexate. I am researching RA drugs for my book.  I give myself injections of 25mg methotrexate weekly. I was opening a new box and preparing to give myself an injection.  Impulsively, I decided to read the insert. Methotrexate has become the gold  standard for RA treatment. It has been one of the few drugs to help relieve my symptoms. Imagine my surprise when I read the following. Medication guide insert with boxed  methotrexate; “Although methotrexate clearly ameliorates symptoms of inflammation (pain, swelling, stiffness), there is no evidence that it induces remission of rheumatoid arthritis nor has a beneficial effect been demonstrated on bone erosions and other radiologic changes which result in impaired joint use, functional disability, and deformity.” So since it doesn’t stop RA progression how can it be classified as a DMARD, Disease Modifying Anti Rheumatic Drug?  Shouldn’t it be a NSAID,  Non-Steroidal Anti-Inflammatory Drug?

Four years of RA

  I was diagnosed with RA four years ago, this month. The first few years were whirlwinds as I was also diagnosed with two cancers that each involved surgery and radiation treatments.  My RA moved to the back seat then to the front and again back and forth. Now it is center stage.   In 2015, I was started on infusions of Orencia. Once I realized that the biologics only help your RA by about 50%, I settled in and appreciated that they helped that much. In July the next year, I developed a horrific flu. I haven’t had a flu for years. It was exhausting. Plus, the Orencia was not working any more. I started having bad flares. My rheumatologist stopped the Orencia. After a few weeks, I was started on infusions of Remicade, a TNF inhibitor. By the third loading dose, I was having a severe flare plus I was having a bad reaction to the Remicade. I was ill. It took two months for the Remicade to clear my system and for …