The thirteenth black box warning for methotrexate is soft tissue necrosis.
Glucocorticoids are naturally produced by the body. For those with RA the body does not produce enough during inflammation. Synthetics, such as, Medrol and prednisone are prescribed.
Not long ago those with RA suffered in agony as their bodies became mutilated . We now have a variety of drugs to reduce those symptoms. Let’s take a closer look at what these drugs are doing.
Anakinra is a biologic medication developed to treat rheumatoid arthritis. Unlike the other RA biologics , it is injected daily.
RA biologics affecting your interleukin 6: Actemra and Kevzara.
The following are targeted biologics approved for rheumatoid arthritis. Targeted means these drugs dampen a particular part of the body’s overactive inflammatory process. Rituxan Orencia Actemra Kevzara Kineret Some of the biologics will not work for you although they work for some other people. Some biologics work for a short time then stop working. Some biologics work for years then seem to stop working suddenly. Sometimes an insurance company will stop covering certain biologics and insist a patient use a limited selection from their formulary. Some people are affected by the possible, serious side effects of these drugs. These complications happen to somebody so pay attention when your doctor briefly mentions them. Doctors do not know which drugs will work for you. Docs give it their best shot. It is trial and error. There is no system to finding the biologic that will work for you. This is the current medical scenario. In this article we will discuss Rituxan and Orencia. Rituxan (Rituximab) In 1982, Rituxan was created by Ronald Levy for the express purpose …
Next line in the treatment of RA TNF inhibitors/TNF blockers are a group of biologic medicines that suppress the body’s response to TNF. TNF (Tumor Necrosis Factor) is a complex protein produced by the white blood cells in response to inflammatory events in the body. Those who have rheumatoid arthritis may be given a TNF inhibitor as part of their therapy. This is the third article in a series about the treatment options for rheumatoid arthritis. You can download the articles or you can read them on Marysarthritis.com. Many insurance plans may require that you start your therapy with a nonbiologic such as methotrexate (MTX). As troublesome as the side effects are in the beginning, methotrexate has a good success rate. When MTX isn’t enough the doctor may order a combination of methotrexate with sulfasalazine and/or leflunomide. A TNF inhibitor may be the added to the methotrexate. Although the TNF inhibitors are basically similar, they do have differentproperties. If one doesn’t work for you, another might. Your doctor will order a TB test and will …
This article is second in the series on rheumatoid arthritis drugs. The four common DMARDs: methotrexate, hydroxychloroquine, sulfasalazine, leflunomide.
This article is the first in a series of articles about RA treatments.
I published this series of posts during the year I was on Orencia. The following are my experiences. August 2015-August 2016 Tomorrow I have my first infusion of Orencia. It is a biologic used to relieve symptoms and slow the joint destruction of Rheumatoid Arthritis. I have just read the medical insert for Orencia. The studies are hopeful. (Having statistics in college finally pays off. The infusion will take 30 minutes. My son is going with me. He is good company and a morale booster. In two weeks I will have another infusion. At one month I will start infusions monthly. I will be happy to have the infusions as long as they help. I have read endless online comments of those who have taken Orencia. They have met with success for the most part. Success means less pain, less disability. It means more energy. It means more life. Orencia , after three months I knew Orencia was working for me one week after my first infusion. Swelling in my hands, ankles and feet gradually …